Vitamin D Deficiency and COVID Mortality

A new study has shown that vitamin D deficiency is associated with mortality when it comes to COVID-19. The study used genetic risk factors to analyze the link between the two. This data is sourced from complex statistics within the UK BioBank. It is restricted to those of White European descent.

Vitamin D plays an important role in the body’s immune system function. It is known to enhance the function of immune cells. Vitamin D inhibits some of the inflammation that can make COVID-19 more severe.

It is estimated that around 25% of the population can be labeled as deficient in Vitamin D.

The study found that vitamin D deficiency was associated with higher mortality due to various conditions such as COVID, cancer, and cardiovascular disease.

Some interesting takeaways from this study include:

  1. It was concluded that the optimal level of vitamin D for reducing mortality is 50 nmoles/ml.
  2. The human genome contains over 13,000 cell receptor sites that are known to be useful in binding vitamin D.
  3. One of the most important receptor targets that are involved in regulating blood pressure is the renin/angiotenin system. In addition, vitamin D metabolism can affect macrophage differentiation, which could contribute to vascular cholesterol accumulation.
  4. The conversion of vitamin D from serum to 1,25-OH2D3 by respiratory epithelial cells can then produce peptides that can protect one from infection.
  5. In order to reduce cancer and covid mortality, active vitamin D can play a role in various cellular processes. These include cell proliferation, differentiation, and apoptosis.

It is becoming clear to the medical community that Vitamin D deficiency may very well have played a role in the severity of COVID infection as well as the number of COVID-related deaths since 2020.

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